Description

1-n-Fmoc-3-Piperidone is a key fluoromethyl-protected piperidone derivative, widely recognized as a crucial building block in modern organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex nitrogen-containing heterocycles, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to develop new active ingredients and functional molecules. The reliable synthesis and high purity of this intermediate are critical for ensuring the success of downstream research and manufacturing processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and anti-cancer drug candidates.
• Peptidomimetics & PROTACs: Serves as a core scaffold for designing peptide mimics and Proteolysis-Targeting Chimeras (PROTACs), enabling targeted protein degradation.
• Alkaloid Synthesis: Used in the construction of complex piperidine-based natural products and alkaloid analogs for biological screening.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying enzyme function and biological pathways.
• Agrochemical Research: Acts as a building block for novel herbicides, fungicides, and insecticides that require specific piperidine motifs.
• Material Science: Potential monomer or cross-linking agent in the synthesis of specialty polymers with unique thermal or mechanical properties.
• Academic & Contract Research: A staple reagent in university and CRO (Contract Research Organization) laboratories for method development and discovery chemistry.

Basic Information

Product Name	1-n-Fmoc-3-Piperidone
CAS No.	672310-11-1
Molecular Formula	C₂₀H₁₉NO₃
Molecular Weight	321.37 g/mol
Synonyms	1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidone; 1-Fmoc-3-piperidone; 1-(9-Fluorenylmethoxycarbonyl)-3-piperidone; 3-Oxopiperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; N-Fmoc-3-piperidone; 1-N-Fmoc-piperidin-3-one; Fmoc-3-piperidone; Piperidin-3-one, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 1-n-Fmoc-3-Piperidone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with the standards expected in pharmaceutical development, supporting your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.