Description

α-Tosyl-(2,6-Difluorobenzyl)Isocyanide is a specialized organic building block featuring a reactive isocyanide group protected by a tosyl moiety and a difluorobenzyl substituent. This compound matters for its utility as a key intermediate in the synthesis of complex heterocycles and functional molecules via multicomponent reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of drug candidates, particularly for constructing imidazole, oxazole, and other nitrogen-containing heterocycles via Ugi and Passerini-type multicomponent reactions.
• Agrochemical Research: Used in the development of novel active ingredients, where the difluorobenzyl group can enhance biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a versatile building block for creating activity-based probes, protein labeling agents, and bioconjugation tools.
• Material Science: Employed in the research and development of functional polymers, ligands for catalysis, and advanced organic frameworks.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and discovery chemistry within university and CRO laboratories.

Basic Information

Product Name	α-Tosyl-(2,6-Difluorobenzyl)Isocyanide
CAS No.	668990-76-9
Molecular Formula	C15H11F2NO2S
Molecular Weight	307.32 g/mol
Synonyms	2,6-Difluoro-α-tosylbenzyl isocyanide; 1-Isocyano-2,6-difluoro-1-(4-methylphenylsulfonyl)methylbenzene; (2,6-Difluorophenyl)(tosylmethyl) isocyanide; α-Tosyl-2,6-difluorobenzyl isocyanide; Tosyl(2,6-difluorobenzyl) isocyanide; 2,6-Difluoro-α-(p-toluenesulfonyl)benzyl isocyanide; (2,6-Difluorobenzyl)(p-tolylsulfonyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our α-Tosyl-(2,6-Difluorobenzyl)Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.