Description

Carbamic Acid, [(1S,3Z)-1-Formyl-3-Pentenyl]-, 1,1-Dimethylethyl Ester (9Ci) is a specialized chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex, stereochemically defined molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the life sciences sector who require high-purity, structurally precise intermediates for API synthesis, peptide mimetics, and medicinal chemistry programs. The CAS number for this material is 666718-89-4.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting neurological and metabolic disorders.
• Peptidomimetics & PROTACs: Serves as a versatile building block for designing and synthesizing peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its formyl and protected carbamate functionalities.
• Asymmetric Synthesis: Utilized in catalytic asymmetric reactions to introduce specific stereocenters into complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Agrochemical Research: Potential intermediate in the development of novel, chiral active ingredients for crop protection.

Basic Information

Product Name	Carbamic Acid, [(1S,3Z)-1-Formyl-3-Pentenyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	666718-89-4
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	(3Z)-1-[(tert-Butoxycarbonyl)amino]-4-penten-1-al; (S,Z)-1-((tert-Butoxycarbonyl)amino)pent-3-en-1-al; tert-Butyl N-[(1S,3Z)-1-formylpent-3-en-1-yl]carbamate; Boc-L-2-Aminopent-4-enal; (S)-1-((tert-Butoxycarbonyl)amino)pent-3-enal; Boc-Protected 2-Aminopentenal; (S,Z)-Boc-Amino-pentenal; 666718-89-4
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and structural integrity, critical for downstream pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral GC/HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and other critical parameters. We support development and commercial projects with material suitable for research use through to cGMP-compliant manufacturing scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); containers must be sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC/GC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.