Description

Carbamic Acid, [(Tetrahydro-2H-Pyran-4-Yl)Methyl]-, 1,1-Dimethylethyl Ester is a high-purity, protected carbamate building block of significant value in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex pharmaceutical molecules, particularly those targeting central nervous system disorders. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to construct novel active pharmaceutical ingredients (APIs) and other bioactive compounds with precision and reliability.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric applications.
• Peptidomimetic Synthesis: Used to introduce the tetrahydro-2H-pyran-4-ylmethyl moiety, a common pharmacophore, into peptide-like structures to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies.
• API Development: Employed in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) requiring protected amine functionalities.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for client projects.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides a base-labile protecting group for amines, integral to complex multi-step synthetic routes.

Basic Information

Item	Details
Product Name	Carbamic Acid, [(Tetrahydro-2H-Pyran-4-Yl)Methyl]-, 1,1-Dimethylethyl Ester
CAS No.	666262-72-2
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	N-[(Tetrahydro-2H-pyran-4-yl)methyl]carbamic acid tert-butyl ester; tert-Butyl N-[(oxan-4-yl)methyl]carbamate; 4-[(tert-Butoxycarbonylamino)methyl]tetrahydro-2H-pyran; Boc-4-(aminomethyl)tetrahydropyran; Boc-THP-methylamine; (Tetrahydro-2H-pyran-4-ylmethyl)carbamic acid tert-butyl ester; N-Boc-4-(aminomethyl)tetrahydropyran; tert-Butyl (tetrahydro-2H-pyran-4-ylmethyl)carbamate
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(Tetrahydro-2H-Pyran-4-Yl)Methyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.