Description

1H-Pyrrolo[2,3-B]Pyridine, 3-Iodo-1-[(4-Methylphenyl)Sulfonyl]- is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its dual functionality, featuring a reactive iodo substituent and a sulfonyl-protected nitrogen, making it a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, particularly in the synthesis of novel kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in the development of kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable functional groups.
• Agrochemical Synthesis: Serves as a precursor in the development of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein functions.
• Material Science: Potential intermediate for the synthesis of organic electronic materials and advanced polymers with specific optoelectronic properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 3-Iodo-1-[(4-Methylphenyl)Sulfonyl]-
CAS No.	664982-01-8
Molecular Formula	C14H11IN2O2S
Molecular Weight	398.22 g/mol
Synonyms	3-Iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-3-iodo-7-azaindole; 3-Iodo-1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-1-[(4-methylphenyl)sulfonyl]-; 3-Iodo-7-azaindole-1-tosylate; 664982-01-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 3-Iodo-1-[(4-Methylphenyl)Sulfonyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to prevent decomposition. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.