Description

Arterolane CAS NO 664338-39-0 is a synthetic ozonide antimalarial compound, representing a significant advancement in the treatment of drug-resistant malaria. Its core value lies in its novel mechanism of action, which provides a critical therapeutic option against Plasmodium falciparum strains resistant to conventional artemisinin-based therapies. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing next-generation antimalarial formulations and conducting pharmacological studies.

Application

• Antimalarial Drug Formulation: Primary active ingredient in solid oral dosage forms (e.g., tablets, capsules) for the treatment of uncomplicated and severe malaria.
• Combination Therapy Development: Used in research and production of fixed-dose combination (FDC) therapies, often paired with other antimalarial agents like piperaquine, to enhance efficacy and prevent resistance.
• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in preclinical and clinical studies investigating new malaria treatment protocols.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods to assay drug products.
• Mechanism of Action Studies: Critical for biochemical and parasitological research aimed at understanding ozonide activity and parasite resistance mechanisms.

Basic Information

Product Name	Arterolane
CAS No.	664338-39-0
Molecular Formula	C₁₃H₁₈F₃N₃O₃
Molecular Weight	321.29 g/mol
Synonyms	Arterolane; OZ277; RBx 11160; 1,2,4-Trioxolane, 3-(2-((4-fluorophenyl)ethyl)-3-(4-fluorophenyl)-5-(4-pyridinyl)-, (3R,5S)-rel-; (3R,5S)-3-(2-(4-Fluorophenyl)ethyl)-3-(4-fluorophenyl)-5-(pyridin-4-yl)-1,2,4-trioxolane
EINECS	Contact for details

Quality Control

Our Arterolane is manufactured under strict quality management systems to meet the exacting standards required for pharmaceutical active ingredients. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and ICH Q3 guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. The container should be kept in a well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.