Description

Pyridine, 5-Ethynyl-2-Methoxy- (9Ci) is a specialized pyridine derivative featuring an ethynyl substituent, serving as a versatile and valuable building block in advanced organic synthesis. Its unique molecular structure makes it a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for its role in cross-coupling reactions and as a precursor to more complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of conductive polymers, organic semiconductors, and metal-organic frameworks (MOFs).
• Ligand Synthesis: Employed in the creation of specialized ligands for catalysis, particularly in palladium-catalyzed cross-coupling reactions like Sonogashira couplings.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries.
• Fluorescent Probe Development: The ethynyl group allows for further functionalization to create dyes and molecular probes for biochemical sensing and imaging.

Basic Information

Product Name	Pyridine, 5-Ethynyl-2-Methoxy- (9Ci)
CAS No.	663955-59-7
Molecular Formula	C8H7NO
Molecular Weight	133.15 g/mol
Synonyms	5-Ethynyl-2-methoxypyridine; 2-Methoxy-5-ethynylpyridine; 5-Ethynyl-2-pyridinol methyl ether; 2-Pyridinol, 5-ethynyl-, methyl ether (9CI); 5-Ethynyl-2-methoxypyridine (9CI)
EINECS	Contact for details

Quality Control

Our production of Pyridine, 5-Ethynyl-2-Methoxy- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry for identity confirmation and impurity profiling. Certificates of Analysis (COA) detailing purity, assay, and related substances are provided with each shipment and are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.