Description

α-Tosyl-(2,3-Difluorobenzyl)Isocyanide is a specialized organic building block featuring a reactive isocyanide group protected by a tosyl moiety and a difluorobenzyl substituent. This compound matters for its utility as a key intermediate in the synthesis of complex heterocycles and pharmaceuticals, particularly through multicomponent reactions like the Ugi and Passerini reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of drug candidates and active pharmaceutical ingredients (APIs) via isocyanide-based multicomponent reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides by providing a versatile fluorinated isocyanide building block.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and molecular tags for studying biological systems.
• Material Science: Serves as a precursor for creating functionalized polymers and advanced organic materials with specific electronic or surface properties.
• Academic & Contract Research: A valuable tool for methodological development in organic synthesis and discovery chemistry within university and CRO laboratories.

Basic Information

Product Name	α-Tosyl-(2,3-Difluorobenzyl)Isocyanide
CAS No.	660431-67-4
Molecular Formula	C15H11F2NO2S
Molecular Weight	307.32 g/mol
Synonyms	α-Tosyl-2,3-difluorobenzyl isocyanide; 2,3-Difluoro-α-tosylbenzyl isocyanide; 1-Isocyano-1-(2,3-difluorophenyl)-2-(p-tolylsulfonyl)ethane; 1-(2,3-Difluorophenyl)-2-(4-methylphenylsulfonyl)ethyl isocyanide; (2,3-Difluorobenzyl)(tosylmethyl) isocyanide; TosMIC derivative, 2,3-difluoro; p-Toluenesulfonyl(2,3-difluorobenzyl) isocyanide
EINECS	Contact for details

Quality Control

Our α-Tosyl-(2,3-Difluorobenzyl)Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and light-sensitive nature, store the product in a cool, dry, and well-ventilated place at a recommended temperature of 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.