Description

α-Tosyl-(2,4-Difluorobenzyl)Isocyanide is a specialized organic building block featuring a reactive isocyanide group protected by a tosyl group and a difluorobenzyl moiety. This compound is valued for its role as a key intermediate in multi-component reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and pharmacophores. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of novel drug candidates, particularly in the construction of nitrogen-containing heterocycles via Ugi and Passerini reactions.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its ability to introduce complex molecular diversity.
• Chemical Biology & Proteomics: Serves as a versatile building block for creating activity-based probes and molecular tags to study biological systems.
• Material Science: Employed in the research and development of advanced organic materials and functional polymers.
• Academic & Contract Research: Essential for methodological development in organic synthesis and for producing custom compounds in research laboratories.

Basic Information

Product Name	α-Tosyl-(2,4-Difluorobenzyl)Isocyanide
CAS No.	660431-66-3
Molecular Formula	C15H11F2NO2S
Molecular Weight	307.32 g/mol
Synonyms	2,4-Difluoro-α-[(isocyanomethyl)sulfonyl]toluene; 2,4-Difluoro-α-tosylmethyl isocyanide; (2,4-Difluorobenzyl)(tosyl)methyl isocyanide; α-Tosyl-2,4-difluorobenzyl isocyanide; Tosyl(2,4-difluorobenzyl)methyl isocyanide; NSC 797886; (2,4-Difluorophenyl)methyl[(4-methylphenyl)sulfonyl]methyl isocyanide
EINECS	Contact for details

Quality Control

Our α-Tosyl-(2,4-Difluorobenzyl)Isocyanide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.