Description

[1-(2-Fluorophenyl)-1-Tosyl]Methyl Isocyanide is a specialized organic building block featuring a unique combination of fluorophenyl, tosyl, and isocyanide functional groups. This compound is of significant value in advanced organic synthesis, particularly for the construction of complex heterocyclic scaffolds and pharmacophores. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for lead optimization and the discovery of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging the bioactivity of the fluorinated aromatic system.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Multicomponent Reactions (MCRs): An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot generation of diverse chemical libraries.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Used to create isocyanide-based probes for studying biological processes and protein labeling.

Basic Information

Item	Details
Product Name	[1-(2-Fluorophenyl)-1-Tosyl]Methyl Isocyanide
CAS No.	660431-65-2
Molecular Formula	C15H12FNO2S
Molecular Weight	289.32 g/mol
Synonyms	1-Isocyano-1-(2-fluorophenyl)-1-tosylethane; [1-(2-Fluorophenyl)-1-(p-tolylsulfonyl)]methyl isocyanide; (2-Fluorophenyl)(tosyl)methyl isocyanide; α-Isocyano-2-fluorobenzyl p-tolyl sulfone; 1-(2-Fluorophenyl)-1-(4-methylphenylsulfonyl)methyl isocyanide; Tosyl(2-fluorophenyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our [1-(2-Fluorophenyl)-1-Tosyl]Methyl Isocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.