Description

2-Bromo-3,5-Difluoropyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a highly valuable intermediate for introducing specific molecular motifs. This compound is essential for research and development chemists and process engineers working in the pharmaceutical and agrochemical sectors. It enables the synthesis of complex molecules with tailored properties for active ingredient development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoropyridine core.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs, due to the electron-withdrawing nature of the halogenated pyridine ring.
• Fluorinated Building Block: A valuable reagent for introducing both bromine and fluorine functional groups into more complex molecular architectures via subsequent substitution or cross-coupling reactions.

Basic Information

Product Name	2-Bromo-3,5-Difluoropyridine
CAS No.	660425-16-1
Molecular Formula	C5H2BrF2N
Molecular Weight	193.98 g/mol
Synonyms	3,5-Difluoro-2-bromopyridine; 2-Bromo-3,5-difluoropyridine; Pyridine, 2-bromo-3,5-difluoro-; 660425-16-1; 2-Bromo-3,5-difluoropyridine; 3,5-Difluoro-2-bromopyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,5-Difluoropyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.