Description

5-Chloro-2-Fluoro-4-Iodopyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other bioactive heterocycles.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and kinase inhibitors.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or functionalization agent for creating specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Synthesis: Versatile scaffold for further functionalization to create libraries of novel pyridine-based compounds for drug discovery.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Iodopyridine
CAS No.	659731-48-3
Molecular Formula	C5H2ClFIN
Molecular Weight	273.43 g/mol
Synonyms	4-Iodo-5-chloro-2-fluoropyridine; 2-Fluoro-5-chloro-4-iodopyridine; 5-Chloro-2-fluoro-4-iodopyridine; Pyridine, 5-chloro-2-fluoro-4-iodo-; 659731-48-3
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluoro-4-Iodopyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.