Description

3-Pyridinecarboxamide,6-Methyl-n-[(1R,2S)-2-Phenylcyclopropyl]-,Rel-(9Ci) CAS NO 658683-88-6 is a high-purity, chiral organic compound featuring a pyridinecarboxamide core with a substituted phenylcyclopropyl group. This specific stereochemistry makes it a valuable advanced pharmaceutical intermediate for the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical synthesis facilities focused on creating targeted therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those targeting neurological or metabolic pathways.
• Chiral Synthesis: Serves as a stereochemically defined precursor for creating enantiomerically pure compounds in medicinal chemistry.
• Research & Development: Used in academic and industrial R&D for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying biological processes and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	3-Pyridinecarboxamide,6-Methyl-n-[(1R,2S)-2-Phenylcyclopropyl]-,Rel-(9Ci)
CAS No.	658683-88-6
Molecular Formula	C16H16N2O
Molecular Weight	252.31 g/mol
Synonyms	N-[(1R,2S)-2-Phenylcyclopropyl]-6-methyl-3-pyridinecarboxamide; (1R,2S)-N-(2-Phenylcyclopropyl)-6-methylnicotinamide; 6-Methyl-N-[(1R,2S)-2-phenylcyclopropyl]nicotinamide; rel-(1R,2S)-N-(2-Phenylcyclopropyl)-6-methylpyridine-3-carboxamide; 3-Pyridinecarboxamide, 6-methyl-N-[(1R,2S)-2-phenylcyclopropyl]-, rel-; 658683-88-6; 6-Methyl-N-[(1R,2S)-2-phenylcyclopropyl]pyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical and chiral purity suitable for sensitive pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.