Description

3-Pyridinecarboxamide,2-Amino-n-[(1R,2S)-2-Phenylcyclopropyl]-,Rel-(9Ci) is a chiral, stereochemically defined organic compound featuring a pyridinecarboxamide core linked to a phenylcyclopropyl moiety. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate (API intermediate) and a critical building block in medicinal chemistry research. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers for the synthesis of novel drug candidates, particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Asymmetric Synthesis: Utilized as a building block requiring specific stereochemistry for the construction of complex, biologically active molecules.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis projects for client-specific molecules.

Basic Information

Product Name	3-Pyridinecarboxamide,2-Amino-n-[(1R,2S)-2-Phenylcyclopropyl]-,Rel-(9Ci)
CAS No.	658683-87-5
Molecular Formula	C15H15N3O
Molecular Weight	253.30 g/mol
Synonyms	2-Amino-N-[(1R,2S)-2-phenylcyclopropyl]pyridine-3-carboxamide; (1R,2S)-2-Amino-N-(2-phenylcyclopropyl)nicotinamide; rel-(1R,2S)-2-Amino-N-(2-phenylcyclopropyl)nicotinamide; 2-Amino-N-[(1R,2S)-2-phenylcyclopropyl]-3-pyridinecarboxamide; 3-Pyridinecarboxamide, 2-amino-N-[(1R,2S)-2-phenylcyclopropyl]-, rel-; 658683-87-5; A chiral phenylcyclopropyl nicotinamide derivative
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with full analytical data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.