Description

Bicyclo[4.1.0]Heptane-3-Carboxylic Acid, Methyl Ester, (1R,3S,6R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters for its rigid bicyclic framework and defined stereochemistry, which are critical for constructing complex molecular architectures with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions to introduce the bicyclo[4.1.0]heptane scaffold into target molecules.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore the impact of a constrained, fused ring system on biological activity and pharmacokinetic properties.
• Agrochemical Research: Utilized in the synthesis of advanced intermediates for novel herbicides, fungicides, or insecticides requiring specific stereochemistry.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new chemical space in discovery programs.

Basic Information

Product Name	Bicyclo[4.1.0]Heptane-3-Carboxylic Acid, Methyl Ester, (1R,3S,6R)-Rel- (9Ci)
CAS No.	657391-47-4
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	rel-(1R,3S,6R)-Methyl bicyclo[4.1.0]heptane-3-carboxylate; Methyl (1R,3S,6R)-rel-bicyclo[4.1.0]heptane-3-carboxylate; Bicyclo[4.1.0]heptane-3-carboxylic acid, methyl ester, (1R,3S,6R)-rel-; Methyl rel-(1R,3S,6R)-bicyclo[4.1.0]heptane-3-carboxylate; (1R,3S,6R)-rel-Methyl bicyclo[4.1.0]heptane-3-carboxylate; CAS 657391-47-4
EINECS	Contact for details

Quality Control

Our Bicyclo[4.1.0]Heptane-3-Carboxylic Acid, Methyl Ester, (1R,3S,6R)-Rel- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including chiral purity analysis, to confirm identity and specification compliance. Certificates of Analysis (COA) detailing specific results for each batch are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.