Description

Methyl 3-(6-Aminopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate is a high-purity, protected amino acid derivative featuring both a tert-butoxycarbonyl (Boc) protecting group and a methyl ester. This compound is a critical pharmaceutical intermediate designed for the synthesis of complex molecules, offering chemists a versatile building block with orthogonal protecting groups for selective deprotection. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for peptide mimetics and small molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially in oncology and neurology research.
• Peptidomimetic Synthesis: Used to incorporate modified amino acid structures into peptide chains to enhance metabolic stability and bioavailability.
• Protecting Group Chemistry: The Boc group provides acid-labile protection for the amine functionality, enabling sequential synthesis strategies.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.
• Chemical Biology Probes: Utilized in the development of labeled compounds or probes for studying biological pathways and target engagement.

Basic Information

Product Name	Methyl 3-(6-Aminopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate
CAS No.	656801-29-5
Molecular Formula	C14H20N2O4
Molecular Weight	280.32 g/mol
Synonyms	Methyl 2-((tert-butoxy)carbonyl)-3-(6-aminopyridin-2-yl)propanoate; 2-(Boc)-3-(6-amino-2-pyridyl)propionic Acid Methyl Ester; Boc-3-(6-Amino-2-pyridyl)-Ala-OMe; Methyl 3-(6-Amino-2-pyridyl)-2-(tert-butoxycarbonyl)propionate; 656801-29-5; 2-Pyridinepropanoic acid, 6-amino-α-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester; Methyl α-[[(1,1-dimethylethoxy)carbonyl]amino]-6-amino-2-pyridinepropanoate
EINECS	Contact for details

Quality Control

Our Methyl 3-(6-Aminopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the exacting standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.