Description

Methyl 3-(6-Bromopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate is a high-value, multi-functional chemical intermediate featuring both a bromopyridine moiety and a protected amino acid ester. This compound is essential for facilitating complex synthetic transformations in advanced organic chemistry, offering a versatile handle for cross-coupling reactions and further functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, leveraging the reactivity of the bromine atom for structural diversification.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers used in the development of specialty polymers and advanced materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Peptidomimetic Chemistry: The tert-butoxycarbonyl (Boc) protected amino ester functionality is crucial for constructing peptide analogs and conformationally constrained molecules.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.

Basic Information

Product Name	Methyl 3-(6-Bromopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate
CAS No.	656801-28-4
Molecular Formula	C14H18BrNO4
Molecular Weight	344.20 g/mol
Synonyms	Methyl 2-((tert-butoxycarbonyl)amino)-3-(6-bromopyridin-2-yl)propanoate; 2-(Boc-amino)-3-(6-bromo-2-pyridyl)propionic acid methyl ester; Boc-6-Br-2-Pyridyl-Ala-OMe; Methyl N-Boc-3-(6-bromopyridin-2-yl)-L-alaninate; 656801-28-4; Methyl 3-(6-bromo-2-pyridinyl)-2-[[(1,1-dimethylethoxy)carbonyl]amino]propanoate; Propanoic acid, 3-(6-bromo-2-pyridinyl)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-(6-Bromopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade production for pharmaceutical applications, with documentation tailored to meet stringent regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.