Description

Methyl 3-(5-Bromopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate is a high-value, multi-functional chemical intermediate designed for advanced synthetic applications. Its molecular architecture, featuring both a bromopyridine moiety and a tert-butoxycarbonyl (Boc) protected amino acid ester, makes it a critical building block for constructing complex pharmacologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the bioactive pyridine core.
• Peptidomimetics & PROTACs: Serves as a versatile building block for creating peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to its Boc-protected amino acid ester functionality.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Investigated for the development of advanced organic materials and functionalized polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific chiral or functionalized intermediates.

Basic Information

Product Name	Methyl 3-(5-Bromopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate
CAS No.	656801-27-3
Molecular Formula	C15H20BrNO4
Molecular Weight	358.23 g/mol
Synonyms	Methyl 3-(5-bromo-2-pyridinyl)-2-[[(1,1-dimethylethoxy)carbonyl]amino]propanoate; 2-((tert-Butoxycarbonyl)amino)-3-(5-bromopyridin-2-yl)propanoic acid methyl ester; Boc-5-Br-Phe(2-Py)-OMe; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(5-bromopyridin-2-yl)propanoic acid methyl ester (for enantiopure form); Methyl 2-(Boc-amino)-3-(5-bromo-2-pyridyl)propionate; 656801-27-3; Boc-5-Bromopyridylalanine methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(5-Bromopyridin-2-Yl)-2-(tert-Butoxycarbonyl)Propanoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All materials are fully characterized and undergo rigorous analytical testing, including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light) and should be handled under inert conditions if prolonged exposure is anticipated to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.