Description

2-Methyl-6-((Trimethylsilanyl)Ethynyl)Pyridine is a specialized organosilicon pyridine derivative that serves as a valuable synthon and ligand in advanced chemical synthesis. Its core value lies in the unique reactivity of the ethynylsilane group combined with the coordinating ability of the pyridine ring, enabling precise molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those requiring silicon-containing moieties or metal-catalyzed coupling reactions.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides where the trimethylsilylethynyl group introduces favorable metabolic properties.
• Ligand for Catalysis: Acts as a supporting ligand in transition metal catalysis, such as palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Heck).
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers, organic semiconductors, and metal-organic frameworks (MOFs).
• Organic Synthesis Reagent: Employed in academic and industrial R&D for introducing protected acetylene functionalities into complex molecular architectures.
• Surface Modification: Used to functionalize surfaces (e.g., silicon wafers, nanoparticles) via silane chemistry for sensor or electronic applications.

Basic Information

Product Name	2-Methyl-6-((Trimethylsilanyl)Ethynyl)Pyridine
CAS No.	656800-40-7
Molecular Formula	C11H15NSi
Molecular Weight	189.33 g/mol
Synonyms	2-Methyl-6-((trimethylsilyl)ethynyl)pyridine; 6-((Trimethylsilyl)ethynyl)-2-picoline; 2-Methyl-6-(trimethylsilylethynyl)pyridine; 2-Picoline, 6-((trimethylsilyl)ethynyl)-; 2-Methyl-6-(2-trimethylsilylethynyl)pyridine; 6-Ethynyl-2-methylpyridine trimethylsilyl derivative; TMS-ethynyl-2-methylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-6-((Trimethylsilanyl)Ethynyl)Pyridine is manufactured and analyzed under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemicals and advanced intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.