Description

α-Tosyl-(4-Iodomethylbenzyl)Isocyanide is a specialized organic building block featuring both isocyanide and tosyl-protected iodomethylbenzyl functional groups. This compound is valued for its versatility as a key intermediate in multi-component reactions and modern synthetic methodologies, enabling the efficient construction of complex heterocyclic and pharmaceutical scaffolds. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for libraries of nitrogen-containing heterocycles.
• Agrochemical Research: Used in the development of new active ingredients and fungicides through multi-component reaction chemistry.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioorthogonal labeling and the creation of activity-based probes.
• Material Science: Employed in the synthesis of functional polymers and advanced organic materials with tailored properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, including Ugi-type and Passerini reactions.

Basic Information

Product Name	α-Tosyl-(4-Iodomethylbenzyl)Isocyanide
CAS No.	655254-68-5
Molecular Formula	C16H14INO2S
Molecular Weight	427.26 g/mol
Synonyms	4-(Isocyanomethyl)benzyl 4-methylbenzenesulfonate iodide; 4-(Tosyloxymethyl)benzyl Isocyanide Iodide; p-Toluenesulfonic Acid 4-(Isocyanomethyl)benzyl Ester Iodide; (4-Isocyanobenzyl) Tosylate Iodide; TOSMIC Benzyl Iodide Derivative; α-Tosyl-4-iodomethylbenzyl Isocyanide; 4-[(Isocyanidomethyl)phenyl]methyl 4-methylbenzenesulfonate iodide
EINECS	Contact for details

Quality Control

Our α-Tosyl-(4-Iodomethylbenzyl)Isocyanide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom purity grades or analytical packages are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.