Description

Benzamide, n-[(6R)-6,7-Dihydro-5H-Cyclopenta[B]Pyridin-6-Yl]-4-Fluoro- (9Ci) is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs). The compound, identified by CAS No. 654675-40-8, is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting kinase inhibition or central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique fused bicyclic structure and fluorine substituent.
• Preclinical Development: Serves as a critical precursor for scaling up the production of potential active pharmaceutical ingredients (APIs) for toxicology and formulation studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for studying specific enzyme functions or protein interactions in biological systems.

Basic Information

Item	Details
Product Name	Benzamide, n-[(6R)-6,7-Dihydro-5H-Cyclopenta[B]Pyridin-6-Yl]-4-Fluoro- (9Ci)
CAS No.	654675-40-8
Molecular Formula	C15H13FN2O
Molecular Weight	256.28 g/mol
Synonyms	4-Fluoro-N-[(6R)-6,7-dihydro-5H-cyclopenta[b]pyridin-6-yl]benzamide; (R)-4-Fluoro-N-(6,7-dihydro-5H-cyclopenta[b]pyridin-6-yl)benzamide; N-[(6R)-6,7-Dihydro-5H-cyclopenta[b]pyridin-6-yl]-4-fluorobenzamide; Benzamide, N-[(6R)-6,7-dihydro-5H-cyclopenta[b]pyridin-6-yl]-4-fluoro-; (R)-N-(6,7-Dihydro-5H-cyclopenta[b]pyridin-6-yl)-4-fluorobenzamide; CAS 654675-40-8
EINECS	Contact for details

Quality Control

Our Benzamide, n-[(6R)-6,7-Dihydro-5H-Cyclopenta[B]Pyridin-6-Yl]-4-Fluoro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.