Description

4(1H)-Pyridinone, 3-Hydroxy-2-Methyl-1-[(2S,5S)-Tetrahydro-5-(Hydroxymethyl)-2-Furanyl]- (9Ci) is a high-purity, complex heterocyclic compound featuring a fused pyridinone and tetrahydrofuran structure, making it a valuable chiral building block for advanced synthesis. This compound is critical for research and development in pharmaceutical chemistry, particularly in the creation of novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements. It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting infectious diseases or metabolic disorders.
• Medicinal Chemistry Research: Used as a scaffold or precursor for constructing complex molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of optically active pharmaceutical compounds.
• Academic & Institutional Research: Utilized in studies focusing on asymmetric synthesis, heterocyclic chemistry, and the development of new catalytic methodologies.
• Fine Chemical Synthesis: Acts as a specialized starting material for the production of other high-value, complex organic molecules with defined stereochemistry.

Basic Information

Item	Details
Product Name	4(1H)-Pyridinone, 3-Hydroxy-2-Methyl-1-[(2S,5S)-Tetrahydro-5-(Hydroxymethyl)-2-Furanyl]- (9Ci)
CAS No.	654054-86-1
Molecular Formula	C11H15NO4
Molecular Weight	225.24 g/mol
Synonyms	3-Hydroxy-2-methyl-1-[(2S,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-4(1H)-pyridinone; (2S,5S)-5-(Hydroxymethyl)-2-[(3-hydroxy-2-methyl-4-oxo-4H-pyridin-1-yl)]tetrahydrofuran; 1-((2S,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)-3-hydroxy-2-methylpyridin-4(1H)-one; A potential pharmaceutical intermediate based on its CAS registry.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ state-of-the-art analytical techniques, including HPLC, GC, and chiral analysis, to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), chiral purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.