Description

2-Piperidinone, 4-Hydroxy-6-(1-Methylethyl)-, (4R,6R)- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. Its defined stereochemistry at the 4 and 6 positions makes it a critical building block for the development of complex, biologically active molecules. This compound is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for projects requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric synthesis to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for candidate drugs, from laboratory to pilot plant scale.
• Fine Chemical Synthesis: Employed in the production of other high-value, specialty fine chemicals and advanced intermediates requiring this specific stereochemistry.

Basic Information

Product Name	2-Piperidinone, 4-Hydroxy-6-(1-Methylethyl)-, (4R,6R)- (9Ci)
CAS No.	653589-30-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(4R,6R)-4-Hydroxy-6-isopropylpiperidin-2-one; (4R,6R)-4-Hydroxy-6-(1-methylethyl)-2-piperidinone; (4R,6R)-6-Isopropyl-4-hydroxypiperidin-2-one; (4R,6R)-4-Hydroxy-6-isopropyl-2-piperidinone; (4R,6R)-4-Hydroxy-6-(propan-2-yl)piperidin-2-one; (4R,6R)-HPP; trans-4-Hydroxy-6-isopropyl-2-piperidinone (specific stereoisomer)
EINECS	Contact for details

Quality Control

Our production of (4R,6R)-4-Hydroxy-6-isopropylpiperidin-2-one adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (4R,6R)-isomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.