Description

(E)-5-Hydroxy-7H-Pyrido[2,3-B]Azepin-8(9H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Integral to the process development and scale-up of potential Active Pharmaceutical Ingredients (APIs), especially for targeted therapies.
• Biochemical Research: Employed in biochemical assays and as a tool compound for investigating specific biological pathways and enzyme interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(E)-5-Hydroxy-7H-Pyrido[2,3-B]Azepin-8(9H)-One
CAS No.	652976-28-8
Molecular Formula	C10H10N2O2
Molecular Weight	190.20 g/mol
Synonyms	(E)-5-Hydroxy-7,8,9,10-tetrahydroazepino[2,3-b]pyridin-8-one; 5-Hydroxy-7H-pyrido[2,3-b]azepin-8(9H)-one, (E)-; Azepino[2,3-b]pyridin-8-one derivative; 652976-28-8; (E)-isomer of 5-Hydroxy-7H-pyrido[2,3-b]azepin-8(9H)-one
EINECS	Contact for details

Quality Control

Our (E)-5-Hydroxy-7H-Pyrido[2,3-B]Azepin-8(9H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.