Description

2-Bromo-5-Fluoro-3-Nitropyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique halogenated and nitrated pyridine structure, which enables precise molecular modifications in the development of novel active compounds. It is critically needed by research chemists and process developers in the pharmaceutical and agrochemical industries for creating new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Aromatic Substitution: The fluorine and nitro groups activate the ring for selective substitution, enabling diverse chemical transformations.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies in academic and CRO laboratories.

Basic Information

Product Name	2-Bromo-5-Fluoro-3-Nitropyridine
CAS No.	652160-72-0
Molecular Formula	C5H2BrFN2O2
Molecular Weight	220.98 g/mol
Synonyms	2-Bromo-5-fluoro-3-nitropyridine; 3-Nitro-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromo-3-nitropyridine; Pyridine, 2-bromo-5-fluoro-3-nitro-; 652160-72-0; 2-Br-5-F-3-NO2-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoro-3-Nitropyridine is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.