Description

5-Chloropyridine-2-Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to introduce the 5-chloropyridin-2-yl moiety into target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate halogenated pyridine scaffolds.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic semiconductors, where precise molecular architecture is required.
• Chemical Biology Probes: Useful for constructing molecular probes and bioconjugates for studying biological systems and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	5-Chloropyridine-2-Boronic Acid Pinacol Ester
CAS No.	652148-93-1
Molecular Formula	C11H15BClNO2
Molecular Weight	239.51 g/mol
Synonyms	5-Chloro-2-pyridineboronic acid pinacol ester; (5-Chloropyridin-2-yl)boronic acid pinacol ester; 2-(5-Chloropyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Chloropyridine-2-boronic acid neopentyl glycol ester (common alternative); 652148-93-1; 5-Cl-Py-2-Bpin
EINECS	Contact for details

Quality Control

Our 5-Chloropyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR, to ensure it meets the high standards required for sensitive cross-coupling reactions. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.