Description

6-Bromo-3-(Bromomethyl)-1,2-Benzisoxazole is a high-purity, multi-functional brominated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic cores found in potential drug candidates, particularly in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive bromomethyl and bromo sites for further functionalization.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The bromine substituents make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	6-Bromo-3-(Bromomethyl)-1,2-Benzisoxazole
CAS No.	651780-00-6
Molecular Formula	C8H5Br2NO
Molecular Weight	290.94 g/mol
Synonyms	3-(Bromomethyl)-6-bromo-1,2-benzisoxazole; 6-Bromo-3-(bromomethyl)benzo[d]isoxazole; 1,2-Benzisoxazole, 6-bromo-3-(bromomethyl)-; 651780-00-6; 6-Bromo-3-bromomethylbenzisoxazole
EINECS	Contact for details

Quality Control

Our 6-Bromo-3-(Bromomethyl)-1,2-Benzisoxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.