Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, organosilicon-protected heterocyclic building block of significant importance in advanced organic synthesis. This compound is specifically engineered to provide a reactive handle for the controlled functionalization of the pyrrolopyridine core, a privileged scaffold in medicinal chemistry. It is an essential intermediate for research and development chemists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of drug candidates targeting kinase inhibition, central nervous system (CNS) disorders, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides due to the bioactive nature of the pyrrolopyridine scaffold.
• Material Science Precursor: Serves as a functional monomer or ligand precursor in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the creation of tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.
• Academic & R&D Laboratories: Used in methodological development and exploratory synthesis of novel heterocyclic compounds in university and industrial research settings.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	651744-48-8
Molecular Formula	C16H25ClN2Si
Molecular Weight	308.92 g/mol
Synonyms	4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-4-chloro-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1H-pyrrolo[2,3-b]pyridine, 1-(triisopropylsilyl)-; 1-(Triisopropylsilyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine; TIPS-4-Chloro-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-1-TIPS-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable batch-to-batch consistency for your development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.