Description

4-Fluoro-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, fluorinated heterocyclic building block characterized by its sulfonyl-protected pyrrolopyridine core. This compound is essential for advanced pharmaceutical research and development, particularly in the synthesis of novel small molecule therapeutics targeting a range of diseases. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its fluorinated, fused-ring system.
• Agrochemical Research: Serves as a building block for developing new generation herbicides, fungicides, and insecticides with enhanced properties.
• Chemical Biology: Employed as a probe or linker in the development of chemical tools for studying biological pathways and protein function.
• Material Science: Potential precursor for organic electronic materials or advanced polymers requiring specific fluorinated aromatic components.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences industry.

Basic Information

Product Name	4-Fluoro-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	651744-26-2
Molecular Formula	C₁₅H₁₁FN₂O₂S
Molecular Weight	302.32 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 4-fluoro-1-(phenylsulfonyl)-; 4-Fluoro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-4-fluoro-1H-pyrrolo[2,3-b]pyridine; 4-Fluoro-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl) derivative; 651744-26-2; 4-Fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common name variant)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.