Description

1H-Pyrrolo[2,3-B]Pyridin-5-Ol, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where precise molecular architecture is paramount. Its primary utility lies in the pharmaceutical and agrochemical R&D sectors, enabling the construction of complex molecules with high regioselectivity and functional group tolerance.

Application

• Pharmaceutical Intermediate: A key protected synthon in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides that require specific fluorinated heterocyclic cores.
• Material Science Precursor: Serves as a specialized monomer or ligand precursor for creating functional organic electronic materials and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Directed Ortho Metalation (DoM): The silyl protecting group facilitates regioselective functionalization of the core heterocycle, a crucial step in medicinal chemistry.
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags or molecular probes for studying biological systems and enzyme activity.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridin-5-Ol, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	651744-22-8
Molecular Formula	C16H25FN2OSi
Molecular Weight	308.47 g/mol
Synonyms	4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol; 4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol; 1-(Triisopropylsilyl)-4-fluoro-1H-pyrrolo[2,3-b]pyridin-5-ol; 4-Fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridin-5-ol; TIPS-protected 4-fluoro-7-azaindol-5-ol; 651744-22-8; 4-Fluoro-1H-pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Every lot is characterized using advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.