Description

Methyl n-Boc-3-Chloro-L-Alaninate is a protected amino acid derivative, specifically a methyl ester of Boc-protected 3-chloro-L-alanine. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the 3-chloroalanine moiety into more complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and other biologically active molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the non-proteinogenic amino acid 3-chloroalanine into peptide chains for structure-activity relationship (SAR) studies.
• Agrochemical Research: Serves as a building block for creating novel herbicides, fungicides, or insecticides that require a specific chiral halogenated amino acid structure.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes (ABPs) or labeled compounds for studying enzyme mechanisms and protein interactions.
• Academic & R&D: A valuable reagent for methodological development in asymmetric synthesis and for exploring new reactions involving protected halogenated amino acids.

Basic Information

Product Name	Methyl n-Boc-3-Chloro-L-Alaninate
CAS No.	651035-84-6
Molecular Formula	C9H16ClNO4
Molecular Weight	237.68 g/mol
Synonyms	(2S)-Methyl 3-chloro-2-[(tert-butoxycarbonyl)amino]propanoate; L-Alanine, 3-chloro-, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Methyl (2S)-3-chloro-2-[(tert-butoxycarbonyl)amino]propanoate; Boc-3-chloro-L-alanine methyl ester; N-Boc-3-chloro-L-alanine methyl ester; tert-Butyl (1S)-1-(chloromethyl)-2-methoxy-2-oxoethylcarbamate; (S)-Methyl 3-chloro-2-((tert-butoxycarbonyl)amino)propanoate
EINECS	Contact for details

Quality Control

Our Methyl n-Boc-3-Chloro-L-Alaninate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.