Description

6-Methyl-5-(4-Phenyl-1,3-Thiazol-2-Yl)-2-(Trifluoromethyl)Nicotinic Acid is a high-value, multifunctional heterocyclic building block featuring a nicotinic acid core substituted with a trifluoromethyl group and a phenyl-thiazole moiety. This compound is critical for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals due to its unique structural and electronic properties. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical manufacturers, and fine chemical synthesis specialists for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, neurology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for developing specialty chemicals, ligands for catalysis, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis projects and scale-up production under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	6-Methyl-5-(4-Phenyl-1,3-Thiazol-2-Yl)-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	651004-85-2
Molecular Formula	C₁₇H₁₁F₃N₂O₂S
Molecular Weight	364.34 g/mol
Synonyms	2-(Trifluoromethyl)-6-methyl-5-[4-phenyl-1,3-thiazol-2-yl]nicotinic acid; 5-(4-Phenyl-1,3-thiazol-2-yl)-6-methyl-2-(trifluoromethyl)pyridine-3-carboxylic acid; 651004-85-2; 6-Methyl-5-(4-phenylthiazol-2-yl)-2-(trifluoromethyl)nicotinic acid; Nicotinic acid, 6-methyl-5-(4-phenyl-2-thiazolyl)-2-(trifluoromethyl)-; TCI-A2175; AKOS005258065
EINECS	Contact for details

Quality Control

Our production of 6-Methyl-5-(4-Phenyl-1,3-Thiazol-2-Yl)-2-(Trifluoromethyl)Nicotinic Acid adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high purity for research and commercial use. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.