Description

cis-2-Amino-Cyclooctanecarboxylic Acid is a specialized, non-proteinogenic amino acid derivative featuring a constrained cyclooctane ring system. This unique bicyclic structure makes it a valuable chiral building block and scaffold in advanced organic synthesis and medicinal chemistry research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel peptide mimetics, bioactive compounds, and as a ligand in asymmetric catalysis.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for creating conformationally constrained peptides.
• Peptidomimetics & Drug Discovery: Used to design and synthesize peptide analogs with enhanced metabolic stability, bioavailability, and target selectivity by introducing rigid cyclic structures.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands or organocatalysts used in enantioselective synthesis to produce optically pure compounds.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme mechanisms, protein-protein interactions, and other biological processes.
• Material Science Research: Explored as a monomer or building block for novel polymers and functional materials with specific stereochemical properties.
• Academic & Industrial R&D: A critical reagent for methodological development in organic synthesis and for exploring new chemical space in corporate and university laboratories.

Basic Information

Product Name	cis-2-Amino-Cyclooctanecarboxylic Acid
CAS No.	649765-17-3
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	(1R,2S)-2-Aminocyclooctanecarboxylic Acid; (1S,2R)-2-Aminocyclooctanecarboxylic Acid; cis-2-Aminocyclooctane-1-carboxylic Acid; 2-Aminocyclooctanecarboxylic Acid, cis-; ACC (cis-); Cyclooctane amino acid derivative; Bicyclic non-proteinogenic amino acid
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical products. Each batch of cis-2-Amino-Cyclooctanecarboxylic Acid is analyzed to ensure high chemical purity and chiral integrity, meeting the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.