Description

2-(Hydroxymethyl)-6-[4-(Trifluoromethyl)Phenyl]Pyridine is a specialized heterocyclic building block featuring a hydroxymethyl group and a trifluoromethylphenyl substituent. This compound matters for its role as a key intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs, due to its conjugated pyridine core.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and fluorescent tags to study biological processes and enzyme functions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Item	Detail
Product Name	2-(Hydroxymethyl)-6-[4-(Trifluoromethyl)Phenyl]Pyridine
CAS No.	648439-11-6
Molecular Formula	C13H10F3NO
Molecular Weight	253.22 g/mol
Synonyms	6-[4-(Trifluoromethyl)phenyl]-2-pyridinemethanol; [6-[4-(Trifluoromethyl)phenyl]-2-pyridinyl]methanol; 2-Pyridinemethanol, 6-[4-(trifluoromethyl)phenyl]-; 2-(Hydroxymethyl)-6-(4-(trifluoromethyl)phenyl)pyridine; 2-(Hydroxymethyl)-6-(α,α,α-trifluoro-p-tolyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-(Hydroxymethyl)-6-[4-(Trifluoromethyl)Phenyl]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.