Description

2H-Pyran-2-One,Tetrahydro-4,5-Dimethyl-6-(1-Methylethyl)-,(4R,5R,6R)-Rel-(9Ci) is a high-purity, stereochemically defined lactone compound of significant interest in advanced organic synthesis. This material matters as a versatile chiral building block and intermediate, enabling the construction of complex molecular architectures with precise stereocontrol. It is primarily needed by research and development laboratories, pharmaceutical companies, and fine chemical manufacturers focused on developing novel active ingredients, flavors, fragrances, and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in classes requiring specific lactone or polyketide-like frameworks.
• Flavor & Fragrance (F&F) Industry: Serves as a precursor for synthesizing complex lactone-based aroma compounds, contributing to creamy, fruity, or coconut-like olfactory notes in premium formulations.
• Agrochemical Synthesis: Used in the development of advanced chiral pesticides and herbicides, where the specific stereochemistry can be critical for biological activity and environmental profile.
• Academic & Industrial Research: Employed as a model substrate or starting material in methodological studies, including asymmetric catalysis, total synthesis, and the exploration of new chemical transformations.
• Fine Chemical Production: Acts as a building block for specialty chemicals, liquid crystals, and advanced polymers requiring specific stereochemical configurations.

Basic Information

Product Name	2H-Pyran-2-One,Tetrahydro-4,5-Dimethyl-6-(1-Methylethyl)-,(4R,5R,6R)-Rel-(9Ci)
CAS No.	648434-46-2
Molecular Formula	C10H16O2
Molecular Weight	168.23 g/mol
Synonyms	(4R,5R,6R)-4,5-Dimethyl-6-(propan-2-yl)tetrahydro-2H-pyran-2-one; (4R,5R,6R)-rel-4,5-Dimethyl-6-isopropyltetrahydro-2H-pyran-2-one; Tetrahydro-4,5-dimethyl-6-(1-methylethyl)-2H-pyran-2-one, (4R,5R,6R)-rel-; 6-Isopropyl-4,5-dimethyltetrahydro-2H-pyran-2-one; 4,5-Dimethyl-6-isopropyltetrahydro-2-pyrone; Stereoisomer of whisky lactone precursor; Chiral lactone intermediate C10H16O2.
EINECS	Contact for details

Quality Control

Our 2H-Pyran-2-One,Tetrahydro-4,5-Dimethyl-6-(1-Methylethyl)-,(4R,5R,6R)-Rel-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, enantiomeric excess (ee), and correct stereochemical identity. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC or GC), chiral purity, and identification are available upon request. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be sensitive to prolonged exposure to heat, moisture, and strong oxidizing agents. Keep the container tightly sealed when not in use to maintain purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (4R,5R,6R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.