Description

2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4-Ol is a high-value heterocyclic building block featuring a tetrahydropyridopyrimidine core with a strategically positioned trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a privileged scaffold for modulating biological activity and improving pharmacokinetic properties. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for target identification and validation in biological systems.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing of complex, high-value specialty chemicals.

Basic Information

Product Name	2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4-Ol
CAS No.	647862-98-4
Molecular Formula	C9H8F3N3O
Molecular Weight	231.18 g/mol
Synonyms	4-Hydroxy-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 2-(Trifluoromethyl)-4-hydroxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 5,6,7,8-Tetrahydro-2-(trifluoromethyl)pyrido[3,4-d]pyrimidin-4-ol; 647862-98-4; Tetrahydropyridopyrimidin-4-ol derivative
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4-Ol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.