Description

Methyl (R)-1-Boc-4,4-Difluoropyrrolidine-2-Carboxylate is a high-value, chiral building block featuring a protected amine and a difluorinated pyrrolidine core. This compound is critical for medicinal chemistry research, enabling the rapid synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutics, particularly in the areas of protease inhibitors and targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting neurological and metabolic diseases.
• Protease Inhibitor Development: Serves as a core scaffold for designing potent inhibitors of various proteases due to its constrained difluoropyrrolidine structure.
• Peptidomimetics: Used to construct peptide analogs where the difluoropyrrolidine moiety mimics proline or other amino acids, improving drug-like properties.
• Agrochemical Research: Employed in the discovery of novel agrochemicals where fluorine incorporation can enhance activity and environmental stability.
• Chemical Biology Probes: Utilized as a building block for creating tool compounds and probes to study biological pathways and enzyme function.
• Asymmetric Synthesis: Acts as a versatile starting material for the preparation of other enantiomerically pure compounds via further functionalization of the ester and protected amine groups.

Basic Information

Product Name	Methyl (R)-1-Boc-4,4-Difluoropyrrolidine-2-Carboxylate
CAS No.	647857-74-7
Molecular Formula	C12H19F2NO4
Molecular Weight	279.28 g/mol
Synonyms	(R)-Methyl 1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylate; (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylic acid methyl ester; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4,4-difluoropyrrolidine-2-carboxylic acid methyl ester; (R)-1-N-Boc-4,4-difluoropyrrolidine-2-carboxylic acid methyl ester; tert-Butyl (2R)-2-(methoxycarbonyl)-4,4-difluoropyrrolidine-1-carboxylate; (R)-Methyl 4,4-difluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl (R)-1-Boc-4,4-Difluoropyrrolidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and NMR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.