Description

(2R)-2-Azetidinecarboxylic Acid Methyl Esterhydrochloride is a high-purity chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in the azetidine ring, a four-membered nitrogen heterocycle that imparts unique conformational and pharmacological properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex chiral molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially those targeting the central nervous system (CNS) and metabolic diseases.
• Protease Inhibitor Synthesis: Used in the construction of scaffolds for protease inhibitors, leveraging the constrained geometry of the azetidine ring.
• Peptidomimetics & Constrained Peptides: Serves as a backbone modification to create rigid, metabolically stable peptide analogs for therapeutic and diagnostic applications.
• Agrochemical Research: Employed as a building block for novel herbicides, fungicides, and plant growth regulators that require specific stereochemistry.
• Ligand & Catalyst Development: Utilized in the synthesis of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	(2R)-2-Azetidinecarboxylic Acid Methyl Esterhydrochloride
CAS No.	647854-63-5
Molecular Formula	C5H10ClNO2
Molecular Weight	151.59 g/mol
Synonyms	Methyl (2R)-azetidine-2-carboxylate hydrochloride; (R)-Methyl azetidine-2-carboxylate hydrochloride; L-Azetidine-2-carboxylic acid methyl ester hydrochloride; (R)-2-(Methoxycarbonyl)azetidine hydrochloride; Azetidine-2-carboxylic acid methyl ester, (R)-, hydrochloride; Methyl L-azetidine-2-carboxylate HCl; (R)-Azetidine-2-carboxylic acid methyl ester HCl
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-Azetidinecarboxylic Acid Methyl Esterhydrochloride is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and cGMP manufacturing applications. Comprehensive analytical testing, including chiral purity verification, is performed. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.