Description

Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1R,2R)- (9Ci) is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its defined stereochemistry and functionalized cyclobutane ring make it a valuable scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its specific stereoconfiguration is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, antiviral agents, and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the stereochemistry of the cyclobutane ring can influence potency and selectivity.
• Asymmetric Catalysis & Ligand Development: Serves as a precursor for chiral ligands or catalysts used in enantioselective synthesis, enabling the production of single-isomer compounds.
• Material Science Research: Investigated as a monomer or building block for novel polymers with unique thermal or mechanical properties derived from the strained cyclobutane structure.
• Fragrance & Flavor Chemistry: Potential intermediate for synthesizing specialty aroma chemicals with complex, musky, or woody odor profiles.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in organic synthesis, including ring-opening and functionalization reactions.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1R,2R)- (9Ci)
CAS No.	647826-42-4
Molecular Formula	C7H12O2
Molecular Weight	128.17 g/mol
Synonyms	(1R,2R)-2-Methylcyclobutanecarboxylic acid methyl ester; Methyl (1R,2R)-2-methylcyclobutanecarboxylate; (1R,2R)-Methyl 2-methylcyclobutanecarboxylate; trans-(1R,2R)-Methyl 2-methylcyclobutanecarboxylate; (1R,2R)-2-Methylcyclobutanecarboxylic Acid Methyl Ester; (1R,2R)-2-Methyl-cyclobutanecarboxylic acid methyl ester; (1R,2R)-rel-2-Methylcyclobutanecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1R,2R)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. All materials are characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.