Description

Methyl 2-Chloro-3-Fluorobenzoate is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. This compound is valued for its role in introducing both chloro and fluoro substituents onto a benzoate scaffold, enabling precise molecular modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the 2-chloro-3-fluoro substitution pattern is critical for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions such as Suzuki, Stille, or Buchwald-Hartwig aminations for constructing complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, exploring new reaction pathways, and creating specialized chemical libraries.
• Fluorine Chemistry Studies: A valuable compound for investigating the unique electronic and steric effects of adjacent chloro and fluoro substituents on aromatic systems.

Basic Information

Product Name	Methyl 2-Chloro-3-Fluorobenzoate
CAS No.	647020-70-0
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-Chloro-3-fluorobenzoic acid methyl ester; Methyl 2-chloro-3-fluorobenzoate; Benzoic acid, 2-chloro-3-fluoro-, methyl ester; Methyl o-chloro-m-fluorobenzoate; 3-Fluoro-2-chlorobenzoic acid methyl ester; Methyl 3-fluoro-2-chlorobenzoate; 647020-70-0; Methyl ester of 2-chloro-3-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-3-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to supply chain integrity and documentation traceability supports your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.