Description

Spiro[1-Azabicyclo[2.2.1]Heptane-2,3-Pyrrolidin]-2-One (9Ci) is a complex, high-purity spirocyclic organic compound with the CAS registry number 646055-81-4. This specialized chemical serves as a critical advanced pharmaceutical intermediate (API) and a versatile scaffold for medicinal chemistry. It is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a privileged spirocyclic scaffold for designing and optimizing new molecular entities in drug discovery programs.
• Neurological & Psychiatric Drug Development: Particularly relevant for creating compounds that interact with central nervous system (CNS) targets.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and protein function.
• Process Chemistry & Scale-Up: Serves as a starting material for process development and optimization in pilot and commercial-scale manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis.

Basic Information

Product Name	Spiro[1-Azabicyclo[2.2.1]Heptane-2,3-Pyrrolidin]-2-One (9Ci)
CAS No.	646055-81-4
Molecular Formula	C9H12N2O
Molecular Weight	164.21 g/mol
Synonyms	Spiro[1-azabicyclo[2.2.1]heptane-2,3'-pyrrolidin]-2'-one; 1-Azaspiro[bicyclo[2.2.1]heptane-2,3'-pyrrolidin]-2'-one; 646055-81-4; Spirocyclic pyrrolidinone; Azaspiro compound; 9CI nomenclature compound; Pharmaceutical intermediate 646055-81-4
EINECS	Contact for details

Quality Control

Every batch of Spiro[1-Azabicyclo[2.2.1]Heptane-2,3-Pyrrolidin]-2-One (9Ci) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.