Description

1'-(3-Pyridinyl)-Spiro[1-Azabicyclo[2.2.1]Heptane-2,3'-Pyrrolidine]Dihydrochloride is a high-purity, complex organic salt primarily utilized as a key intermediate in advanced pharmaceutical research and development. This compound is valued for its unique spirocyclic and bicyclic architecture, which makes it a valuable scaffold for medicinal chemistry and the synthesis of novel active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing new therapeutic agents, particularly in neurological and central nervous system (CNS) applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates targeting nicotinic acetylcholine receptors (nAChRs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Neurological Disorder Research: Employed in the development of potential therapeutics for conditions such as cognitive disorders, pain, and addiction.
• Chemical Biology: Serves as a tool compound for probing biological pathways and protein-ligand interactions in academic and industrial research settings.
• Process Development: Used in scale-up and process chemistry for the commercial production of advanced pharmaceutical intermediates.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1'-(3-Pyridinyl)-Spiro[1-Azabicyclo[2.2.1]Heptane-2,3'-Pyrrolidine]Dihydrochloride
CAS No.	646055-75-6
Molecular Formula	C15H22Cl2N3 • xH2O (Contact for exact hydrate form)
Molecular Weight	Anhydrous: 315.26 g/mol (Contact for details)
Synonyms	Spiro[1-azabicyclo[2.2.1]heptane-2,3'-pyrrolidine], 1'-(3-pyridinyl)-, dihydrochloride; 1'-(Pyridin-3-yl)-3-azaspiro[bicyclo[2.2.1]heptane-2,3'-pyrrolidine] dihydrochloride; 646055-75-6; 1'-(3-Pyridyl)spiro[1-azabicyclo[2.2.1]heptane-2,3'-pyrrolidine] dihydrochloride; TC-2559 dihydrochloride (research code); nAChR ligand intermediate.
EINECS	Contact for details

Quality Control

Our 1'-(3-Pyridinyl)-Spiro[1-Azabicyclo[2.2.1]Heptane-2,3'-Pyrrolidine]Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via spectroscopic methods (IR, NMR, MS), and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.