Description

1-(6'-Aminospiro[Cyclopropane-1,3'-Indolin]-1'-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indoline scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and oncological pathways. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those with spirocyclic or fused indoline structures.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study biological pathways and enzyme functions.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for synthetic methodology development and bioorganic chemistry studies.

Basic Information

Product Name	1-(6'-Aminospiro[Cyclopropane-1,3'-Indolin]-1'-Yl)Ethanone
CAS No.	645419-13-2
Molecular Formula	C12H14N2O
Molecular Weight	202.25 g/mol
Synonyms	1-(6-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone; 1-(6-Amino-1'H-spiro[cyclopropane-1,3'-indol]-1'-yl)ethan-1-one; 1-(6-Amino-1'H-spiro[cyclopropane-1,3'-indol]-1'-yl)ethanone; 1'-Acetyl-6'-aminospiro[cyclopropane-1,3'-indoline]; 6'-Amino-1'-acetylspiro[cyclopropane-1,3'-indoline]; Spiro[cyclopropane-1,3'-indol]-1'-yl ethanone, 6'-amino derivative; CAS 645419-13-2
EINECS	Contact for details

Quality Control

Our 1-(6'-Aminospiro[Cyclopropane-1,3'-Indolin]-1'-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.