Description

n-Boc-4-(p-Fluorophenyl)-4-Piperidinecarboxylic Acid is a high-purity, protected piperidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in providing a versatile, fluorinated aromatic scaffold with orthogonal protecting groups, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex bioactive molecules and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and receptor-targeted drugs.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to introduce fluorinated aromatic and piperidine motifs.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating novel peptide-like compounds with enhanced metabolic stability.
• Agrochemical Development: Employed in the research and development of new herbicides and fungicides that utilize fluorinated aromatic systems.
• Ligand and Catalyst Preparation: Useful for constructing sophisticated ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring a specific, protected fluorophenyl-piperidine carboxylic acid unit.

Basic Information

Product Name	n-Boc-4-(p-Fluorophenyl)-4-Piperidinecarboxylic Acid
CAS No.	644981-89-5
Molecular Formula	C17H22FNO4
Molecular Weight	323.36 g/mol
Synonyms	1-Boc-4-(4-Fluorophenyl)-4-piperidinecarboxylic Acid; 4-(4-Fluorophenyl)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic Acid; tert-Butyl 4-(4-fluorophenyl)-4-(carboxy)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(4-fluorophenyl)-4-piperidinecarboxylic Acid; 4-(4-Fluorophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic Acid; 4-(p-Fluorophenyl)-1-Boc-piperidine-4-carboxylic Acid; BOC-4-(4-Fluorophenyl)-4-piperidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-4-(p-Fluorophenyl)-4-Piperidinecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GLP and cGMP environments, ensuring reliable performance in your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.