Description

10-(Cyanomethyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid CAS NO 643743-39-9 is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is a critical building block in the synthesis of novel fluoroquinolone antibiotics, offering significant value in research and development. It is primarily required by pharmaceutical manufacturers and R&D laboratories focused on developing next-generation antibacterial agents with improved efficacy and spectrum of activity.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key intermediate in the production of advanced fluoroquinolone-class antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of new antibacterial compounds targeting resistant pathogens.
• Process Chemistry & Scale-Up: Serves as a crucial intermediate for process optimization and pilot-scale manufacturing of antibiotic candidates.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations specializing in the production of complex pharmaceutical intermediates.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	10-(Cyanomethyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid
CAS No.	643743-39-9
Molecular Formula	C16H13FN2O4
Molecular Weight	316.29 g/mol
Synonyms	9-Fluoro-10-(cyanomethyl)-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; 10-(Cyanomethyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; Garenoxacin Intermediate; AM-1155 Intermediate; T-3811 Intermediate; 6-Quinolinecarboxylic acid, 2,3-dihydro-9-fluoro-3-methyl-10-[(cyanoacetyl)methyl]-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-; (6S)-9-Fluoro-10-(cyanomethyl)-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (for stereoisomers)
EINECS	Contact for details

Quality Control

Our 10-(Cyanomethyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.