Description

8-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine is a high-purity brominated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its fused dioxino-pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components, due to its electron-rich heterocyclic structure.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	8-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
CAS No.	643067-83-8
Molecular Formula	C7H6BrNO2
Molecular Weight	216.03 g/mol
Synonyms	8-Bromo-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 1,4-Dioxino[2,3-b]pyridine, 8-bromo-2,3-dihydro-; 8-Bromo-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 643067-83-8; 8-Bromo-2,3-dihydro[1,4]dioxino[2,3-b]pyridine; 8-Bromodihydrodioxinopyridine
EINECS	Contact for details

Quality Control

Our 8-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.