Description

Carbamic Acid, [(3R,4S)-3-Hydroxy-4-Piperidinyl]-, 1,1-Dimethylethyl Ester (9Ci) is a high-purity chiral piperidine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its defined stereochemistry and protected functional groups make it an essential building block for the synthesis of complex, biologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold or precursor in drug discovery programs for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions due to its stereogenic centers.
• Protease Inhibitor Development: A potential building block for inhibitors targeting specific enzymatic pathways.
• Chemical Biology: Can be used to create molecular probes for studying biological processes.
• Process Chemistry & Scale-Up: Serves as a validated intermediate for the pilot and commercial-scale production of target drug candidates.

Basic Information

Product Name	Carbamic Acid, [(3R,4S)-3-Hydroxy-4-Piperidinyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	642478-29-3
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	(3R,4S)-3-Hydroxy-4-piperidinylcarbamic acid tert-butyl ester; tert-Butyl N-[(3R,4S)-3-hydroxypiperidin-4-yl]carbamate; (3R,4S)-4-[(tert-Butoxycarbonyl)amino]piperidin-3-ol; BOC-4-amino-3-hydroxypiperidine (stereospecific); (3R,4S)-3-Hydroxy-4-aminopiperidine-1-carboxylic acid tert-butyl ester; (3R,4S)-3-Hydroxy-N-Boc-4-aminopiperidine; (3R,4S)-4-(Boc-amino)-3-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(3R,4S)-3-Hydroxy-4-Piperidinyl]-, 1,1-Dimethylethyl Ester (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.