Description

Ethyl 3-Oxo-3-(3-(Trifluoromethoxy)Phenyl)Propanoate is a high-purity, specialized organic ester compound featuring a trifluoromethoxy-substituted aromatic ketone moiety. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry, enabling the introduction of unique structural motifs. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and insecticides, leveraging the bioactivity of the trifluoromethoxy group.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials requiring specific electronic properties.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Academic & Industrial R&D: A valuable reagent for method development in organic synthesis, including cross-coupling reactions and carbonyl chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	Ethyl 3-Oxo-3-(3-(Trifluoromethoxy)Phenyl)Propanoate
CAS No.	642451-74-9
Molecular Formula	C12H11F3O4
Molecular Weight	276.21 g/mol
Synonyms	Ethyl 3-(3-(Trifluoromethoxy)phenyl)-3-oxopropanoate; 3-Oxo-3-[3-(trifluoromethoxy)phenyl]propionic Acid Ethyl Ester; Ethyl 3-Oxo-3-(3-trifluoromethoxyphenyl)propionate; 3-(3-Trifluoromethoxyphenyl)-3-oxopropionic Acid Ethyl Ester; β-Keto Ester Derivative; TFMPP Ester; CAS 642451-74-9
EINECS	Contact for details

Quality Control

Our production of Ethyl 3-Oxo-3-(3-(Trifluoromethoxy)Phenyl)Propanoate adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high chemical purity. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid / solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.