Description

3-Methylpyridin-2-Yl Trifluoromethanesulfonate (Wxc08960) is a high-purity triflate ester derivative of 3-methylpyridin-2-ol, serving as a versatile and reactive synthetic intermediate. Its primary value lies in its role as a key building block for constructing complex molecules, particularly in pharmaceutical research and advanced material science. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those containing functionalized pyridine cores for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the triflate group enables efficient coupling reactions to introduce complex side chains.
• Ligand and Catalyst Preparation: Serves as a starting material for creating specialized nitrogen-containing ligands used in homogeneous catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or molecular components for OLEDs and sensors.
• Cross-Coupling Reactions: The trifluoromethanesulfonate (triflate) group is an excellent leaving group, making this compound highly valuable in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form carbon-carbon bonds.
• Custom Chemical Synthesis: Provides a handle for further functionalization in contract research and manufacturing (CRO/CMO) for bespoke molecular construction.

Basic Information

Product Name	3-Methylpyridin-2-Yl Trifluoromethanesulfonate (Wxc08960)
CAS No.	640767-55-1
Molecular Formula	C8H8F3NO3S
Molecular Weight	255.21 g/mol
Synonyms	2-(Trifluoromethanesulfonyloxy)-3-methylpyridine; 3-Methyl-2-pyridinyl trifluoromethanesulfonate; 3-Methylpyridin-2-yl triflate; 3-Methyl-2-pyridyl triflate; 2-Pyridinol, 3-methyl-, 1,1,1-trifluoromethanesulfonate (ester); Trifluoromethanesulfonic acid 3-methylpyridin-2-yl ester; WXC-08960
EINECS	Contact for details

Quality Control

Every batch of 3-Methylpyridin-2-Yl Trifluoromethanesulfonate is produced and tested under strict quality management systems. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.