Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, organosilicon-protected heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its role as a key synthetic intermediate, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Development: Used in the research and synthesis of new-generation pesticides and herbicides, leveraging its unique fluorinated pyrrolopyridine core.
• Material Science Research: Serves as a precursor for organic electronic materials and functionalized ligands for catalysis.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies and the exploration of new chemical spaces.
• Custom Synthesis: A starting material for the tailored synthesis of more complex, fluorinated heterocyclic compounds for specialized client projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	640735-25-7
Molecular Formula	C16H25FN2Si
Molecular Weight	292.47 g/mol
Synonyms	4-Fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 4-Fluoro-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-4-fluoro-1H-pyrrolo[2,3-b]pyridine; 4-Fluoro-1H-pyrrolo[2,3-b]pyridine, 1-(triisopropylsilyl)-; TIPS-4-Fluoro-1H-pyrrolo[2,3-b]pyridine; 640735-25-7; 4-Fluoro-1-triisopropylsilyl-7-azaindole
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 4-Fluoro-1-[Tris(1-Methylethyl)Silyl]- adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.